The episode begins in Becca's lab, where Abby, Jackson, Emori, Murphy, Raven, Clarke, Miller, Roan, and Luna begin testing on an unnamed Grounder that Emori marked as "Baylis". It starts off well, he survives the amount of radiation of the black rain. However, when they increase the radiation levels, he dies a violent death, coughing up black blood. The test is deemed a failure.
Meanwhile, at Arkadia, Jaha gathers everyone for the funeral of the eighteen that died in the black rain. Bellamy is conflicted on staying in the camp or following Jasper into the woods. Eventually, Jasper finally manages to convince him to join him, Bellamy only coming to keep an eye on him.
During the funeral, Jaha overhears Niylah repeating the phrase "From the ashes, we will rise," as a prayer. He recalls that phrase from Second Dawn that has made its way into Grounder mythology. Second Dawn and Becca's scientific breakthroughs are linked. Jaha convinces Kane to take him to Indra so they can speak to her daughter Gaia, the current Flamekeeper.
At Becca's lab, Emori's lie about the test subject's identity surfaces, resulting in her and Murphy getting locked up. Emori's fear for being the test subject resurfaces as she knows she is the next test subject. She knows that she's the outsider among them, thus making her expendable, so to save herself, she had to put forth an alternative, but her means of doing so leads to the exact situation that she feared. Having betrayed everyone and tricked them into murdering a Grounder, Emori positions herself as the next in line to be tested in the radiation chamber. The others are quick to choose her as the next test subject, which hints that they always found her expendable. Now they have justification to serve as their right to put her in the radiation chamber.
Jasper and Bellamy are in the woods wandering until dark. After having enough of Jasper's attitude concerning the end of the world, Bellamy decides to stop and talk some sense into him. Jasper explains why he feels that he must embrace the end of the world, and tells him to open his eyes cause "The clock is ticking, and it has been since we landed on this terrible...beautiful planet." When they arrive back at Arkadia, Jasper joins the rest of the others in the party, Bellamy soon joins with Bree and drinks hallucinogenic tea with the rest of the others.
Back at the lab, Luna is not willing to give more of her bone marrow. Roan is forced to fight Luna and knock her unconscious.
In Polis, Jaha, Monty and Kane arrive to find Indra already there waiting for them. Kane walks towards her and she punches him in the face. She explains that her hostility towards him and the sky people is because they made an alliance with her enemy, Azgeda. Kane later explains that he came to speak to her daughter Gaia. She takes them to her.
Gaia explains that the Second Dawn symbol is the holy symbol of their order. It adorns the crypt of the first commander, Becca. The crypt is in the temple. But there is one complication, it's controlled by Azgeda. Kane tells Indra that they have the royal seal and that there'll be no need for a fight.
They are soon stopped by Azgeda. Kane tells them that they seek safe passage to the temple and shows them the royal seal. They allow them to pass. However, this does not convince Indra. At the first chance she gets, she guns them down. Kane is furious, but Indra explains that if there is a bunker inside the temple, Azgeda will never see the inside. She continues ahead, as Jaha urges Kane forward telling him that the war isn't theirs to fight. They enter the temple. Gaia tells them that it's beneath the altar. Jaha digs around and finds the entrance, however, there is one problem. The key won't open the entrance.
In the lab, they are preparing Emori for the radiation chamber. Abby doesn't manage to inject her, so Clarke takes over. After contemplating, she injects herself instead. Her mother is not happy with this. After two hours have passed, Clarke's preparing to be tested. Abby doesn't want to let her go in. She explains that she saw Clarke with radiation poisoning her vision. Abby then smashes the radiation chamber until it's unusable.
Back in Polis, Kane, Jaha, Monty, Indra, and Gaia are about to give up, when Monty has a thought. He ponders for a moment and asks them that what if the phrase "From the ashes, we shall rise" is not a motto, but an instruction? Upon realizing this, Jaha puts the key in the flame, and it burns into a smaller key with the number twelve etched on it. Jaha tries to place it in the keyholder and turns it. It opens up and they enter the bunker.
Jaha: "I know it took courage to be outside with us today, to stand together now in the face of grave danger and grave tragedy. On the Ark, rain like this was only a dream. Now it's a nightmare because we know it could turn at any second and kill us, just like it did to 18 of our brothers and sisters, who we honor today among them, Erin, Samuel, and Louis. May we meet again."
Jasper: "It means we are living on borrowed time, all of us."
Jasper (to Bellamy): "What is the point in beating yourself up over all of the the crappy things you've done? You did them! And and don't say you had reasons, because at the end of the day, at the end of the world, nobody gives a damn about your reasons, because they are your reasons. No matter how much you punish yourself, it's not gonna change anything. It's not gonna bring anyone back. The way I see it is we can spend our last days wallowing in our reasons or we can do – we can do whatever the hell we want! Really mean it this time."
Raven: "Abby, there has to be something that doesn't make us murderers."
Abby: "Jackson and I have examined every possibility. And the only thing that we know for sure is that if we do nothing, we die."
Luna: "I won't allow my blood to kill any more innocent people."
Luna: "Is there no line you won't cross in order to survive?"
God complex is a pop psychology term for the inflated belief of personal ability, privilege, or infallibility. Someone with a god complex may believe that he or she has the ability to overcome any problem or task, despite the high impossibility and probability for failure. They may refuse to admit the possibility of their error or failure, even in the face of irrefutable evidence. They may also speak of their personal opinions as though they are unquestionably correct.
This is the second episode in which Octavia Blake does not appear, after "Terms and Conditions." This makes Clarke and Bellamy the only characters to have appeared in more episodes (each has missed an episode).
In this episode, Clarke injects herself with Luna's bone marrow and becomes a Nightblood. Though Abby destroys the radiation chamber to prevent testing on her daughter, it's subsequently shown that the experiment was a success and Clarke became a true Nightblood.